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ALK1
Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.30; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; STKR family; TKL group; Type1 subfamily |
| Chromosomal Location of mouse Ortholog: 15|15 F1 |
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Cellular Component:
BMP receptor complex; cell surface; dendrite; membrane; neuronal cell body; plasma membrane; receptor complex
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Molecular Function:
activin binding; activin receptor activity, type I; ATP binding; BMP receptor activity; kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; SMAD binding; transferase activity; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor activity, type I; transmembrane receptor protein serine/threonine kinase activity
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Biological Process:
angiogenesis; artery development; blood circulation; blood vessel morphogenesis; blood vessel remodeling; BMP signaling pathway; cellular response to BMP stimulus; cellular response to growth factor stimulus; cellular response to transforming growth factor beta stimulus; dorsal aorta morphogenesis; dorsal/ventral pattern formation; endocardial cushion morphogenesis; endocardial cushion to mesenchymal transition; endothelial cell activation; endothelial tube morphogenesis; heart development; in utero embryonic development; lymphangiogenesis; lymphatic endothelial cell differentiation; negative regulation of blood vessel endothelial cell migration; negative regulation of cell adhesion; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell population proliferation; negative regulation of DNA biosynthetic process; negative regulation of endothelial cell differentiation; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; negative regulation of focal adhesion assembly; negative regulation of gene expression; phosphorylation; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of DNA-templated transcription; positive regulation of endothelial cell differentiation; positive regulation of endothelial cell proliferation; positive regulation of pathway-restricted SMAD protein phosphorylation; positive regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of blood pressure; regulation of DNA-templated transcription; retina vasculature development in camera-type eye; signal transduction; transforming growth factor beta receptor signaling pathway; transmembrane receptor protein serine/threonine kinase signaling pathway; venous blood vessel development; wound healing, spreading of epidermal cells
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Reference #:
Q61288
(UniProtKB)
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Alt. Names/Synonyms: activin A receptor, type II-like 1; Activin receptor-like kinase 1; activin receptor-like kinase-1; Acv; ACVL1; Acvrl1; Acvrlk1; AI115505; AI427544; Alk; ALK-1; Alk1; Serine/threonine-protein kinase receptor R3; SKR3; TGF-B superfamily receptor type I; TSR-I
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Gene Symbols: Acvrl1
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Molecular weight:
56,519 Da
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Basal Isoelectric point:
7.85
Predict pI for various phosphorylation states
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