|
BRAF iso1
Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. Brain and testis. Note: This description may include information from UniProtKB.
|
| Protein type: EC 2.7.11.1; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL |
| Chromosomal Location of mouse Ortholog: 6 B1|6 18.43 cM |
|
Cellular Component:
cell body; cytoplasm; cytosol; intracellular membrane-bounded organelle; membrane; mitochondrion; neuron projection; nucleus; plasma membrane
|
|
Molecular Function:
ATP binding; calcium ion binding; catalytic activity; identical protein binding; kinase activity; MAP kinase kinase activity; MAP kinase kinase kinase activity; metal ion binding; mitogen-activated protein kinase kinase binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; scaffold protein binding; small GTPase binding; transferase activity
|
|
Biological Process:
alpha-beta T cell differentiation; CD4-positive or CD8-positive, alpha-beta T cell lineage commitment; CD4-positive, alpha-beta T cell differentiation; cell differentiation; cellular response to calcium ion; cellular response to xenobiotic stimulus; endothelial cell apoptotic process; epidermal growth factor receptor signaling pathway; ERK1 and ERK2 cascade; establishment of protein localization to membrane; face development; head morphogenesis; long-term synaptic potentiation; MAPK cascade; metabolic process; myeloid progenitor cell differentiation; negative regulation of apoptotic process; negative regulation of endothelial cell apoptotic process; negative regulation of fibroblast migration; negative regulation of neuron apoptotic process; negative regulation of synaptic vesicle exocytosis; phosphorylation; positive regulation of axon regeneration; positive regulation of axonogenesis; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of glucose transmembrane transport; positive regulation of peptidyl-serine phosphorylation; positive regulation of stress fiber assembly; positive regulation of substrate adhesion-dependent cell spreading; positive T cell selection; protein phosphorylation; regulation of axon regeneration; regulation of cell population proliferation; regulation of T cell differentiation; response to cAMP; response to peptide hormone; signal transduction; somatic stem cell population maintenance; stress fiber assembly; substrate adhesion-dependent cell spreading; synaptic vesicle exocytosis; T cell differentiation in thymus; T cell receptor signaling pathway; thymus development; thyroid gland development; trehalose metabolism in response to stress; visual learning
|
|
Reference #:
P28028-1
(UniProtKB)
|
|
Alt. Names/Synonyms: 9930012E13Rik; AA120551; AA387315; AA473386; B-raf; B-Raf proto-oncogene serine/threonine-protein kinase; B-Raf proto-oncogene serine/threonine-protein kinase (p94); Bra; Braf; BRAF iso1; Braf transforming gene; Braf-2; Braf2; C230098H17; C87398; D6Ertd631; D6Ertd631e; Proto-oncogene B-Raf; Serine/threonine-protein kinase B-raf
|
|
Gene Symbols: Braf
|
|
Molecular weight:
88,780 Da
|
|
Basal Isoelectric point:
7.58
Predict pI for various phosphorylation states
|
|
CST Pathways:
ErbB/HER Signaling
|
ESC Pluripotency and Differentiation
|
GPCR Signaling to MAPKs
|
Growth And Differentiation Control by MAPKs
|
IL6 Signaling
|
Inhibition of Apoptosis
|
T Cell Receptor Signaling
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
