ZAK Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Involved in limb development. Isoform 1: Phosphorylates histone H3 at 'Ser-28'. May have role in neoplastic cell transformation and cancer development. Causes cell shrinkage and disruption of actin stress fibers. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.25; Kinase, protein; MLK family; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group; ZAK subfamily
Chromosomal Location of mouse Ortholog: 2|2 C3
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  ATP binding; JUN kinase kinase kinase activity; kinase activity; magnesium ion binding; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein kinase activator activity; protein kinase activity; protein serine/threonine kinase activity; ribosome binding; RNA binding; rRNA binding; small ribosomal subunit rRNA binding; stalled ribosome sensor activity; transferase activity
Biological Process:  cell cycle; cellular response to gamma radiation; cellular response to UV-B; cytoskeleton organization; DNA damage checkpoint signaling; embryonic digit morphogenesis; GCN2-mediated signaling; intracellular signal transduction; JNK cascade; limb development; negative regulation of stress-activated protein kinase signaling cascade; negative regulation of translation in response to endoplasmic reticulum stress; p38MAPK cascade; phosphorylation; positive regulation of apoptotic process; positive regulation of mitotic DNA damage checkpoint; positive regulation of programmed cell death; protein autophosphorylation; protein phosphorylation; pyroptosis; stress-activated MAPK cascade; stress-activated protein kinase signaling cascade
Reference #:  Q9ESL4 (UniProtKB)
Alt. Names/Synonyms: AV006891; B230120H23Rik; HCCS-4; Human cervical cancer suppressor gene 4 protein; Leucine zipper- and sterile alpha motif kinase ZAK; Leucine zipper- and sterile alpha motif-containing kinase; M3K20; Map3k20; Mitogen-activated protein kinase kinase kinase 20; Mitogen-activated protein kinase kinase kinase MLT; Mixed lineage kinase-related kinase; MLK-like mitogen-activated protein triple kinase; MLK-related kinase; Mltk; MLTKalpha; MLTKbe; MLTKbeta; MRK; RIKEN cDNA B230120H23 gene; sterile alpha motif and leucine zipper containing kinase AZK; Sterile alpha motif- and leucine zipper-containing kinase AZK; sterile-alpha motif and leucine zipper containing kinase AZK; Zak
Gene Symbols: Map3k20
Molecular weight: 91,720 Da
Basal Isoelectric point: 7.63  Predict pI for various phosphorylation states
CST Pathways:  SAPK/JNK Signaling Cascades
Select Structure to View Below

ZAK

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene