VEGFR3 Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. Detected in endothelial cells (at protein level). Widely expressed. Detected in fetal spleen, lung and brain. Detected in adult liver, muscle, thymus, placenta, lung, testis, ovary, prostate, heart, and kidney. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; VEGFR family
Chromosomal Location of rat Ortholog: 10q21
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane; receptor complex
Molecular Function:  ATP binding; growth factor binding; protein homodimerization activity; protein phosphatase binding; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor receptor activity
Biological Process:  angiogenesis; blood vessel morphogenesis; cellular response to vascular endothelial growth factor stimulus; hematopoietic progenitor cell differentiation; lung alveolus development; lymph vessel development; lymphangiogenesis; multicellular organism development; negative regulation of apoptotic process; peptidyl-tyrosine phosphorylation; positive regulation of cell growth; positive regulation of cell population proliferation; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of JNK cascade; positive regulation of kinase activity; positive regulation of MAPK cascade; positive regulation of protein kinase C signaling; positive regulation of protein phosphorylation; positive regulation of vascular endothelial growth factor production; protein autophosphorylation; regulation of blood vessel remodeling; respiratory gaseous exchange by respiratory system; respiratory system process; sprouting angiogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor signaling pathway; vasculature development
Reference #:  Q91ZT1 (UniProtKB)
Alt. Names/Synonyms: FLT-4; Flt4; Fms-like tyrosine kinase 4; fms-related tyrosine kinase 4; Tyrosine-protein kinase receptor FLT4; Vascular endothelial growth factor receptor 3; VEGFR-3; Vegfr3; VGFR3
Gene Symbols: Flt4
Molecular weight: 153,317 Da
Basal Isoelectric point: 5.81  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene