ZNF354C May function as a transcription repressor. Binds to 5'-CCACA-3' core sequence. Suppresses osteogenic effects of RUNX2. May be involved in osteoblastic differentiation. Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal. Belongs to the krueppel C2H2-type zinc-finger protein family. Expressed in kidney and skeletal muscle. Very low expression in brain and heart. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component:  cytosol; nuclear membrane
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding
Biological Process:  regulation of transcription by RNA polymerase II
Reference #:  Q86Y25 (UniProtKB)
Alt. Names/Synonyms: hKID3; KID3; Kidney, ischemia, and developmentally-regulated protein 3; KRAB-zinc finger protein synten; Z354C; Zinc finger protein 354C; ZNF354C
Gene Symbols: ZNF354C
Molecular weight: 64,847 Da
Basal Isoelectric point: 8.36  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene