LRRC8D Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8D constitutes a pore-forming subunit or whether it is closely associated with the pore. Mediates the import of the antibiotic blasticidin-S into cell (PubMed:24782309). Belongs to the LRRC8 family. Heterooligomer; heterooligomerizes with other LRRC8 proteins (LRRC8A, LRRC8B, LRRC8C and/or LRRC8E), possibly to form a heterohexamer.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5|5 E5
Cellular Component:  cytoplasm; endoplasmic reticulum; integral component of membrane; integral component of plasma membrane; ion channel complex; membrane; plasma membrane
Molecular Function:  volume-sensitive anion channel activity
Biological Process:  anion transmembrane transport; aspartate transmembrane transport; cell volume homeostasis; cellular response to osmotic stress; ion transport; taurine transport
Reference #:  Q8BGR2 (UniProtKB)
Alt. Names/Synonyms: 2810473G09Rik; 4930525N13Rik; A930019F03; leucine rich repeat containing 5; leucine rich repeat containing 8D; leucine-rich repeat-containing 5; Leucine-rich repeat-containing protein 5; Leucine-rich repeat-containing protein 8D; LRC8D; Lrrc5; Lrrc8d; Volume-regulated anion channel subunit LRRC8D
Gene Symbols: Lrrc8d
Molecular weight: 98,113 Da
Basal Isoelectric point: 7.16  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene