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TrkC
Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Trk family |
| Chromosomal Location of rat Ortholog: 1q31 |
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Cellular Component:
axon; cytoplasm; glutamatergic synapse; Golgi membrane; plasma membrane; postsynaptic membrane; receptor complex
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Molecular Function:
ATP binding; GPI-linked ephrin receptor activity; neurotrophin binding; neurotrophin receptor activity; p53 binding; protein binding; transmembrane receptor protein serine/threonine kinase activity; transmembrane receptor protein tyrosine kinase activity
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Biological Process:
activation of GTPase activity; activation of protein kinase B activity; axon extension involved in regeneration; cell differentiation; cellular response to nerve growth factor stimulus; cellular response to retinoic acid; circadian rhythm; cochlea development; ephrin receptor signaling pathway; heart development; lens fiber cell differentiation; mechanoreceptor differentiation; multicellular organism development; myelination in peripheral nervous system; negative regulation of astrocyte differentiation; negative regulation of protein phosphorylation; nervous system development; neuron fate specification; neuron migration; neuronal action potential propagation; neurotrophin signaling pathway; positive regulation of apoptotic process; positive regulation of axon extension involved in regeneration; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of neuron projection development; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of positive chemotaxis; positive regulation of synapse assembly; postsynaptic density assembly; protein phosphorylation; regulation of neural precursor cell proliferation; regulation of presynapse assembly; regulation of protein kinase B signaling; response to axon injury; response to corticosterone; response to ethanol; transmembrane receptor protein serine/threonine kinase signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
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Reference #:
Q03351
(UniProtKB)
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Alt. Names/Synonyms: GP145-TrkC; neural receptor protein-tyrosine kinase (trkC); neurotrophic receptor tyrosine kinase 3; Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; NT-3 growth factor receptor; Ntrk3; Trk-C; Trkc; TrkC tyrosine kinase
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Gene Symbols: Ntrk3
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Molecular weight:
97,064 Da
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Basal Isoelectric point:
6.15
Predict pI for various phosphorylation states
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CST Pathways:
Tyrosine Kinases & Substrates
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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