TrkC Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Trk family
Chromosomal Location of Human Ortholog: 1q31
Cellular Component:  axon; cytoplasm; glutamatergic synapse; Golgi membrane; integral component of plasma membrane; integral component of postsynaptic membrane; membrane; plasma membrane; receptor complex
Molecular Function:  ATP binding; GPI-linked ephrin receptor activity; neurotrophin binding; neurotrophin receptor activity; p53 binding; protein binding; transmembrane receptor protein serine/threonine kinase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process:  activation of GTPase activity; activation of MAPK activity; activation of protein kinase B activity; cellular response to nerve growth factor stimulus; cellular response to retinoic acid; circadian rhythm; cochlea development; ephrin receptor signaling pathway; heart development; lens fiber cell differentiation; mechanoreceptor differentiation; modulation by virus of host transcription; myelination in peripheral nervous system; negative regulation of astrocyte differentiation; negative regulation of cell death; negative regulation of protein phosphorylation; nervous system development; neuron fate specification; neuron migration; neuronal action potential propagation; neurotrophin signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of actin cytoskeleton reorganization; positive regulation of apoptotic process; positive regulation of axon extension involved in regeneration; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of neuron projection development; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of positive chemotaxis; positive regulation of synapse assembly; regulation of MAPK cascade; regulation of postsynaptic density assembly; regulation of presynapse assembly; response to axon injury; response to corticosterone; response to ethanol; transmembrane receptor protein serine/threonine kinase signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q03351 (UniProtKB)
Alt. Names/Synonyms: GP145-TrkC; neural receptor protein-tyrosine kinase (trkC); neurotrophic receptor tyrosine kinase 3; Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; NT-3 growth factor receptor; Ntrk3; Trk-C; Trkc; TrkC tyrosine kinase
Gene Symbols: Ntrk3
Molecular weight: 97,064 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TrkC

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene