TrkB Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Isoform TrkB is expressed in the central and peripheral nervous system. In the central nervous system (CNS), expression is observed in the cerebral cortex, hippocampus, thalamus, choroid plexus, granular layer of the cerebellum, brain stem, and spinal cord. In the peripheral nervous system, it is expressed in many cranial ganglia, the ophthalmic nerve, the vestibular system, multiple facial structures, the submaxillary glands, and dorsal root ganglia. Isoform TrkB-T1 is mainly expressed in the brain but also detected in other tissues including pancreas, kidney and heart. Isoform TrkB-T-Shc is predominantly expressed in the brain. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Trk family
Chromosomal Location of Human Ortholog: 13 B1|13 31.2 cM
Cellular Component:  axon; axon terminus; cell projection; cell surface; cytoplasm; cytosol; dendrite; dendritic spine; early endosome; endosome; excitatory synapse; glutamatergic synapse; growth cone; integral component of membrane; integral component of plasma membrane; membrane; neuronal cell body; perikaryon; perinuclear region of cytoplasm; plasma membrane; postsynapse; postsynaptic density; postsynaptic membrane; presynaptic active zone; receptor complex; rough endoplasmic reticulum; terminal bouton
Molecular Function:  ATP binding; brain-derived neurotrophic factor binding; brain-derived neurotrophic factor-activated receptor activity; kinase activity; neurotrophin binding; neurotrophin receptor activity; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein tyrosine kinase activity; receptor tyrosine kinase binding; transferase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process:  brain-derived neurotrophic factor receptor signaling pathway; calcium-mediated signaling using intracellular calcium source; cell differentiation; cellular response to amino acid stimulus; cellular response to brain-derived neurotrophic factor stimulus; cellular response to nerve growth factor stimulus; central nervous system neuron development; cerebral cortex development; circadian rhythm; feeding behavior; glutamate secretion; learning; long-term memory; long-term synaptic potentiation; mechanoreceptor differentiation; multicellular organism development; myelination in peripheral nervous system; negative regulation of anoikis; negative regulation of neuron apoptotic process; nervous system development; neuromuscular junction development; neuron differentiation; neuron migration; neuronal action potential propagation; oligodendrocyte differentiation; peripheral nervous system neuron development; phosphorylation; positive regulation of axonogenesis; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of glucocorticoid receptor signaling pathway; positive regulation of MAPK cascade; positive regulation of neuron projection development; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of synapse assembly; positive regulation of synaptic transmission, glutamatergic; protein autophosphorylation; protein phosphorylation; regulation of dendrite development; regulation of GTPase activity; regulation of MAPK cascade; regulation of metabolic process; regulation of neurotransmitter secretion; regulation of protein kinase B signaling; retina development in camera-type eye; retinal rod cell development; trans-synaptic signaling by BDNF, modulating synaptic transmission; trans-synaptic signaling by neuropeptide, modulating synaptic transmission; transmembrane receptor protein tyrosine kinase signaling pathway; vasculogenesis
Reference #:  P15209 (UniProtKB)
Alt. Names/Synonyms: AI848316; BDNF/NT-3 growth factors receptor; C030027L06Rik; GP145-TrkB/GP95-TrkB; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; Ntrk2; Tkr; Tkrb; trk; Trk-B; Trkb; TrkB tyrosine kinase
Gene Symbols: Ntrk2
Molecular weight: 92,133 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TrkB

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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene