TrkB a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Trk family
Chromosomal Location of Human Ortholog: 9q21.33
Cellular Component:  axon; cytosol; dendrite; early endosome; early endosome membrane; Golgi membrane; integral component of plasma membrane; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; receptor complex; terminal bouton
Molecular Function:  ATP binding; brain-derived neurotrophic factor binding; brain-derived neurotrophic factor-activated receptor activity; neurotrophin binding; protein binding; protein homodimerization activity; protein tyrosine kinase activity
Biological Process:  activation of phospholipase C activity; brain-derived neurotrophic factor receptor signaling pathway; cellular response to amino acid stimulus; central nervous system neuron development; cerebral cortex development; circadian rhythm; feeding behavior; glutamate secretion; learning; long-term synaptic potentiation; mechanoreceptor differentiation; myelination in peripheral nervous system; negative regulation of anoikis; negative regulation of neuron apoptotic process; neuron differentiation; neuron migration; neuronal action potential propagation; neurotrophin TRK receptor signaling pathway; oligodendrocyte differentiation; peptidyl-tyrosine phosphorylation; peripheral nervous system neuron development; positive regulation of axonogenesis; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of MAPK cascade; positive regulation of neuron projection development; positive regulation of non-membrane spanning protein tyrosine kinase activity; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphatidylinositol 3-kinase signaling; positive regulation of protein phosphorylation; positive regulation of synapse assembly; protein autophosphorylation; regulation of GTPase activity; retina development in camera-type eye; retinal rod cell development; trans-synaptic signaling by BDNF, modulating synaptic transmission; vasculogenesis
Disease: Epileptic Encephalopathy, Early Infantile, 58; Obesity, Hyperphagia, And Developmental Delay
Reference #:  Q16620 (UniProtKB)
Alt. Names/Synonyms: BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; GP145-TrkB; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; NTRK2; Trk-B; TRKB; TrkB tyrosine kinase; tyrosine kinase receptor B
Gene Symbols: NTRK2
Molecular weight: 91,999 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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