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FKBP12
Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the FKBP-type PPIase family. FKBP1 subfamily. Note: This description may include information from UniProtKB.
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| Protein type: EC 5.2.1.8; Isomerase |
| Chromosomal Location of mouse Ortholog: 2|2 G3 |
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Cellular Component:
axon terminus; cytoplasm; cytosol; membrane; sarcoplasmic reticulum; sarcoplasmic reticulum membrane; synapse; Z disc
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Molecular Function:
activin binding; enzyme binding; FK506 binding; Hsp70 protein binding; identical protein binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity; protein binding; SMAD binding; transforming growth factor beta receptor binding; transmembrane transporter binding; type I transforming growth factor beta receptor binding
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Biological Process:
cytokine-mediated signaling pathway; heart morphogenesis; heart trabecula formation; muscle contraction; protein peptidyl-prolyl isomerization; regulation of ryanodine-sensitive calcium-release channel activity; release of sequestered calcium ion into cytosol; response to caffeine; T cell proliferation; ventricular cardiac muscle tissue morphogenesis
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Reference #:
P26883
(UniProtKB)
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Alt. Names/Synonyms: 12 kDa FK506-binding protein; 12 kDa FKBP; 12kDa; Calstabin-1; FK506 binding protein 12; FK506 binding protein 1a; FK506 binding protein12; FK506 Binding Protein12-T1; FK506 binding protein12-T2; FK506-binding protein 1A; Fkb; FKB1A; Fkbp; FKBP-12; FKBP-1A; Fkbp1; FKBP12; FKBP12-Exip3; FKBP12-T1; FKBP12-T2; Fkbp1a; Immunophilin FKBP12; mFKBP1; mFKBP12; OTTMUSP00000016917; Peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A; Rotamase
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Gene Symbols: Fkbp1a
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Molecular weight:
11,923 Da
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Basal Isoelectric point:
7.89
Predict pI for various phosphorylation states
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CST Pathways:
mTOR Signaling
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Translation: eIF4E and p70S6K
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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