ADK
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides. Belongs to the carbohydrate kinase PfkB family. Widely expressed. Highest level in placenta, liver, muscle and kidney. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell cycle regulation; EC 2.7.1.20; Kinase, other; Nucleotide Metabolism - purine |
Chromosomal Location of human Ortholog: 10q22.2|10q11-q24 |
Cellular Component:
cytosol; nucleoplasm; nucleus; plasma membrane
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Molecular Function:
adenosine kinase activity; ATP binding; deoxyadenosine kinase activity; metal ion binding
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Biological Process:
AMP salvage; dAMP salvage; dATP biosynthetic process; GMP salvage; phosphorylation; purine nucleobase metabolic process; purine ribonucleoside salvage; ribonucleoside monophosphate biosynthetic process
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Disease: Hypermethioninemia Due To Adenosine Kinase Deficiency
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Reference #:
P55263
(UniProtKB)
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Alt. Names/Synonyms: Adenosine 5'-phosphotransferase; Adenosine kinase; ADK; AK; testicular tissue protein Li 14
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Gene Symbols: ADK
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Molecular weight:
40,545 Da
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Basal Isoelectric point:
6.24
Predict pI for various phosphorylation states
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