TIE1 a transmembrane tyrosine-protein kinase that modulates TEK/TIE2 activity and contribute to the regulation of angiogenesis. An endothelial cell specific ligand-receptor necessary for lymphatic development, angiogenesis, vascular remodelling, permeability and inflammation. Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. Three isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Tie family
Chromosomal Location of Human Ortholog: 4 D2.1|4 54.67 cM
Cellular Component:  integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; receptor complex
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process:  angiogenesis; blood vessel development; in utero embryonic development; negative regulation of angiogenesis; negative regulation of cell migration; phosphorylation; plasma membrane fusion; positive regulation of angiogenesis; protein phosphorylation; response to retinoic acid; transmembrane receptor protein tyrosine kinase signaling pathway; vasculogenesis
Reference #:  Q06806 (UniProtKB)
Alt. Names/Synonyms: D430008P04Rik; OTTMUSP00000009169; Tie; Tie-1; Tie1; tyrosine kinase receptor 1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1; Tyrosine-protein kinase receptor Tie-1
Gene Symbols: Tie1
Molecular weight: 124,583 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene