TIE1 Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. Specifically expressed in developing vascular endothelial cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Tie family
Chromosomal Location of mouse Ortholog: 4 D2.1|4 54.67 cM
Cellular Component:  integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; receptor complex
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process:  angiogenesis; blood vessel development; in utero embryonic development; negative regulation of angiogenesis; negative regulation of cell migration; phosphorylation; plasma membrane fusion; positive regulation of angiogenesis; protein phosphorylation; response to retinoic acid; transmembrane receptor protein tyrosine kinase signaling pathway; vasculogenesis
Reference #:  Q06806 (UniProtKB)
Alt. Names/Synonyms: D430008P04Rik; OTTMUSP00000009169; Tie; tie-; Tie-1; Tie1; tyrosine kinase receptor 1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1; Tyrosine-protein kinase receptor Tie-1
Gene Symbols: Tie1
Molecular weight: 124,583 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene