TIE1 a transmembrane tyrosine-protein kinase that modulates TEK/TIE2 activity and contribute to the regulation of angiogenesis. An endothelial cell specific ligand-receptor necessary for lymphatic development, angiogenesis, vascular remodelling, permeability and inflammation. Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. Three isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Tie family
Chromosomal Location of Human Ortholog: 1p34.2
Cellular Component: 
Molecular Function:  ATP binding; protein binding
Biological Process:  in utero embryonic development; mesoderm development; negative regulation of angiogenesis; negative regulation of cell migration; peptidyl-tyrosine phosphorylation; plasma membrane fusion; response to retinoic acid; signal transduction; vasculogenesis
Reference #:  P35590 (UniProtKB)
Alt. Names/Synonyms: JTK14; soluble TIE1 variant 1; soluble TIE1 variant 2; soluble TIE1 variant 3; soluble TIE1 variant 4; soluble TIE1 variant 5; TIE; TIE1; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1; Tyrosine-protein kinase receptor Tie-1
Gene Symbols: TIE1
Molecular weight: 125,090 Da
Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TIE1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene