TIE1 Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. Specifically expressed in developing vascular endothelial cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Tie family
Chromosomal Location of Human Ortholog: 1p34.2
Cellular Component: 
Molecular Function:  ATP binding; protein binding
Biological Process:  in utero embryonic development; mesoderm development; negative regulation of angiogenesis; negative regulation of cell migration; peptidyl-tyrosine phosphorylation; plasma membrane fusion; response to retinoic acid; signal transduction; vasculogenesis
Reference #:  P35590 (UniProtKB)
Alt. Names/Synonyms: JTK14; soluble TIE1 variant 1; soluble TIE1 variant 2; soluble TIE1 variant 3; soluble TIE1 variant 4; soluble TIE1 variant 5; TIE; TIE1; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1; Tyrosine-protein kinase receptor Tie-1
Gene Symbols: TIE1
Molecular weight: 125,090 Da
Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TIE1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene