TIE1 Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. Specifically expressed in developing vascular endothelial cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Tie family
Chromosomal Location of human Ortholog: 1p34.2
Cellular Component:  plasma membrane; receptor complex
Molecular Function:  ATP binding; protein binding; transmembrane receptor protein tyrosine kinase activity
Biological Process:  angiogenesis; aortic valve morphogenesis; branching involved in lymph vessel morphogenesis; in utero embryonic development; lymphatic endothelial cell differentiation; mesoderm development; multicellular organism development; negative regulation of angiogenesis; negative regulation of cell migration; peptidyl-tyrosine phosphorylation; plasma membrane fusion; positive regulation of angiogenesis; positive regulation of kinase activity; regulation of endothelial cell proliferation; regulation of extracellular matrix assembly; response to retinoic acid; signal transduction; tissue remodeling; transmembrane receptor protein tyrosine kinase signaling pathway; vasculogenesis
Disease: Lymphatic Malformation 11
Reference #:  P35590 (UniProtKB)
Alt. Names/Synonyms: JTK14; soluble TIE1 variant 1; soluble TIE1 variant 2; soluble TIE1 variant 3; soluble TIE1 variant 4; soluble TIE1 variant 5; TIE; TIE1; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; tyrosine kinase with immunoglobulin like and EGF like domains 1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1; Tyrosine-protein kinase receptor Tie-1
Gene Symbols: TIE1
Molecular weight: 125,090 Da
Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene