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TIE1
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. Specifically expressed in developing vascular endothelial cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Tie family |
| Chromosomal Location of human Ortholog: 1p34.2 |
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Cellular Component:
plasma membrane; receptor complex
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Molecular Function:
ATP binding; protein binding; transmembrane receptor protein tyrosine kinase activity
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Biological Process:
angiogenesis; aortic valve morphogenesis; branching involved in lymph vessel morphogenesis; in utero embryonic development; lymphatic endothelial cell differentiation; mesoderm development; multicellular organism development; negative regulation of angiogenesis; negative regulation of cell migration; peptidyl-tyrosine phosphorylation; plasma membrane fusion; positive regulation of angiogenesis; positive regulation of kinase activity; regulation of endothelial cell proliferation; regulation of extracellular matrix assembly; response to retinoic acid; signal transduction; tissue remodeling; transmembrane receptor protein tyrosine kinase signaling pathway; vasculogenesis
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Disease: Lymphatic Malformation 11
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Reference #:
P35590
(UniProtKB)
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Alt. Names/Synonyms: JTK14; soluble TIE1 variant 1; soluble TIE1 variant 2; soluble TIE1 variant 3; soluble TIE1 variant 4; soluble TIE1 variant 5; TIE; TIE1; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; tyrosine kinase with immunoglobulin like and EGF like domains 1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1; Tyrosine-protein kinase receptor Tie-1
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Gene Symbols: TIE1
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Molecular weight:
125,090 Da
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Basal Isoelectric point:
6.63
Predict pI for various phosphorylation states
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CST Pathways:
Tyrosine Kinases & Substrates
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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