TACR1 This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P Belongs to the G-protein coupled receptor 1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 2p12
Cellular Component:  cell body; cell surface; cytoplasm; dendrite; plasma membrane; sperm flagellum; sperm head; sperm midpiece
Molecular Function:  protein binding; substance P receptor activity; tachykinin receptor activity
Biological Process:  acute inflammatory response; aggressive behavior; angiotensin-mediated drinking behavior; associative learning; behavioral response to pain; detection of abiotic stimulus; eating behavior; inflammatory response; long-term memory; operant conditioning; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of action potential; positive regulation of blood pressure; positive regulation of cytosolic calcium ion concentration; positive regulation of epithelial cell migration; positive regulation of epithelial cell proliferation; positive regulation of flagellated sperm motility; positive regulation of hormone secretion; positive regulation of leukocyte migration; positive regulation of lymphocyte proliferation; positive regulation of ossification; positive regulation of renal sodium excretion; positive regulation of saliva secretion; positive regulation of stress fiber assembly; positive regulation of synaptic transmission, cholinergic; positive regulation of synaptic transmission, GABAergic; positive regulation of uterine smooth muscle contraction; positive regulation of vascular permeability; positive regulation of vasoconstriction; regulation of smooth muscle cell migration; regulation of smooth muscle cell proliferation; response to auditory stimulus; response to electrical stimulus; response to estradiol; response to ethanol; response to heat; response to morphine; response to nicotine; response to ozone; response to progesterone; sensory perception of pain; smooth muscle contraction involved in micturition; sperm ejaculation; tachykinin receptor signaling pathway
Reference #:  P25103 (UniProtKB)
Alt. Names/Synonyms: neurokinin 1 receptor; neurokinin-1 receptor); NK-1 receptor; NK-1R; NK1R; NKIR; SPR; Substance-P receptor; TAC1R; tachykinin 1 receptor (substance P receptor, neurokinin 1 receptor); Tachykinin receptor 1; tachykinin receptor 1 (substance P receptor; TACR1
Gene Symbols: TACR1
Molecular weight: 46,251 Da
Basal Isoelectric point: 6.78  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein