NR2F2 Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. Interacts with SQSTM1. Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2. Ubiquitous. Belongs to the nuclear hormone receptor family. NR2 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor
Chromosomal Location of Human Ortholog: 15q26.2
Cellular Component:  cytosol; nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; nuclear receptor activity; protein binding; protein homodimerization activity; retinoic acid binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription corepressor activity; zinc ion binding
Biological Process:  anterior/posterior pattern specification; blood vessel morphogenesis; fertilization; forebrain development; intracellular receptor signaling pathway; limb development; lipid metabolic process; maternal placenta development; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; neuron migration; placenta blood vessel development; positive regulation of systemic arterial blood pressure; positive regulation of transcription, DNA-templated; radial pattern formation; regulation of transcription by RNA polymerase II; regulation of transcription involved in lymphatic endothelial cell fate commitment; response to estradiol; signal transduction; skeletal muscle tissue development; steroid hormone mediated signaling pathway; trophoblast giant cell differentiation
Disease: Congenital Heart Defects, Multiple Types, 4
Reference #:  P24468 (UniProtKB)
Alt. Names/Synonyms: ADP-ribosylation factor related protein 1; Apolipoprotein A-I regulatory protein 1; apolipoprotein AI regulatory protein 1; ARP-1; ARP1; chicken ovalbumin upstream promoter transcription factor 2; COT2; COUP transcription factor 2; COUP transcription factor II; COUP-TF II; COUP-TF2; COUPTFB; COUPTFII; MGC117452; NR2F2; Nuclear receptor subfamily 2 group F member 2; nuclear receptor subfamily 2, group F, member 2; SVP40; TFCOUP2
Gene Symbols: NR2F2
Molecular weight: 45,571 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA