SCF Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Belongs to the SCF family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of human Ortholog: 12q21.32
Cellular Component:  cytoplasm; cytoskeleton; extracellular region; extracellular space; filopodium; lamellipodium; plasma membrane
Molecular Function:  cytokine activity; growth factor activity; protein binding; stem cell factor receptor binding
Biological Process:  cell adhesion; ectopic germ cell programmed cell death; embryonic hemopoiesis; extrinsic apoptotic signaling pathway in absence of ligand; hematopoietic progenitor cell differentiation; male gonad development; mast cell apoptotic process; mast cell migration; mast cell proliferation; melanocyte migration; myeloid leukocyte differentiation; negative regulation of mast cell apoptotic process; neural crest cell migration; ovarian follicle development; peptidyl-tyrosine phosphorylation; positive regulation of cell population proliferation; positive regulation of hematopoietic progenitor cell differentiation; positive regulation of hematopoietic stem cell proliferation; positive regulation of leukocyte migration; positive regulation of MAP kinase activity; positive regulation of mast cell proliferation; positive regulation of melanocyte differentiation; positive regulation of myeloid leukocyte differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of T cell proliferation; Ras protein signal transduction; response to organic cyclic compound; T cell proliferation
Disease: Deafness, Autosomal Dominant 69; Hyperpigmentation, Familial Progressive, 2; Skin/hair/eye Pigmentation, Variation In, 7; Waardenburg Syndrome, Type 2f
Reference #:  P21583 (UniProtKB)
Alt. Names/Synonyms: c-Kit ligand; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; Kit ligand; Kitl; KITLG; KL-1; Mast cell growth factor; MGF; SCF; SF; SHEP7; sKITLG; SLF; Soluble KIT ligand; steel factor; Stem cell factor
Gene Symbols: KITLG
Molecular weight: 30,899 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  G2/M DNA Damage Checkpoint
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein