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SCF
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. Belongs to the SCF family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
| Chromosomal Location of human Ortholog: 12q21.32 |
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Cellular Component:
cytoplasm; cytoskeleton; extracellular region; extracellular space; filopodium; lamellipodium; plasma membrane
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Molecular Function:
cytokine activity; growth factor activity; protein binding; stem cell factor receptor binding
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Biological Process:
cell adhesion; ectopic germ cell programmed cell death; embryonic hemopoiesis; extrinsic apoptotic signaling pathway in absence of ligand; hematopoietic progenitor cell differentiation; male gonad development; mast cell apoptotic process; mast cell migration; mast cell proliferation; melanocyte migration; myeloid leukocyte differentiation; negative regulation of mast cell apoptotic process; neural crest cell migration; ovarian follicle development; peptidyl-tyrosine phosphorylation; positive regulation of cell population proliferation; positive regulation of hematopoietic progenitor cell differentiation; positive regulation of hematopoietic stem cell proliferation; positive regulation of leukocyte migration; positive regulation of MAP kinase activity; positive regulation of mast cell proliferation; positive regulation of melanocyte differentiation; positive regulation of myeloid leukocyte differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of Ras protein signal transduction; positive regulation of T cell proliferation; Ras protein signal transduction; response to organic cyclic compound; T cell proliferation
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Disease: Deafness, Autosomal Dominant 69; Hyperpigmentation, Familial Progressive, 2; Skin/hair/eye Pigmentation, Variation In, 7; Waardenburg Syndrome, Type 2f
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Reference #:
P21583
(UniProtKB)
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Alt. Names/Synonyms: c-Kit ligand; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; Kit ligand; Kitl; KITLG; KL-1; Mast cell growth factor; MGF; SCF; SF; SHEP7; sKITLG; SLF; Soluble KIT ligand; steel factor; Stem cell factor
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Gene Symbols: KITLG
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Molecular weight:
30,899 Da
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Basal Isoelectric point:
5.86
Predict pI for various phosphorylation states
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CST Pathways:
G1/S Checkpoint
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G2/M DNA Damage Checkpoint
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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