NDUFV2
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I 24 kDa subunit family. Note: This description may include information from UniProtKB.
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Protein type: EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase |
Chromosomal Location of human Ortholog: 18p11.22 |
Cellular Component:
mitochondrial inner membrane; mitochondrial respiratory chain complex I; mitochondrion
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Molecular Function:
2 iron, 2 sulfur cluster binding; electron transfer activity; metal ion binding; NADH dehydrogenase (ubiquinone) activity; NADH dehydrogenase activity; protein binding
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Biological Process:
aerobic respiration; cardiac muscle tissue development; mitochondrial electron transport, NADH to ubiquinone; nervous system development; proton motive force-driven mitochondrial ATP synthesis
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Disease: Mitochondrial Complex I Deficiency, Nuclear Type 7
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Reference #:
P19404
(UniProtKB)
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Alt. Names/Synonyms: CI-24k; complex I 24kDa subunit; complex I, mitochondrial respitory chain, 24 kD subunit; MC1DN7; NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; NADH dehydrogenase ubiquinone flavoprotein 2, mitochondrial; NADH-ubiquinone oxidoreductase 24 kDa subunit; NADH-ubiquinone oxidoreductase flavoprotein 2; NADH:ubiquinone oxidoreductase core subunit V2; NDUFV2; NDUV2; nuclear-encoded mitochondrial NADH-ubiquinone reductase 24Kd subunit
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Gene Symbols: NDUFV2
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Molecular weight:
27,392 Da
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Basal Isoelectric point:
8.22
Predict pI for various phosphorylation states
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