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FCER1A
Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
| Chromosomal Location of mouse Ortholog: 1 H3|1 80.33 cM |
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Cellular Component:
cell surface; external side of plasma membrane; membrane; membrane raft; plasma membrane
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Molecular Function:
high-affinity IgE receptor activity; IgE binding; IgE receptor activity; protein binding; transmembrane signaling receptor activity
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Biological Process:
calcium-mediated signaling; cell surface receptor signaling pathway; eosinophil degranulation; establishment of localization in cell; granulocyte macrophage colony-stimulating factor production; interleukin-3 production; leukotriene biosynthetic process; mast cell cytokine production; mast cell degranulation; peptidyl-tyrosine phosphorylation; positive regulation of calcium-mediated signaling; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of interleukin-3 production; positive regulation of JUN kinase activity; positive regulation of MAP kinase activity; positive regulation of mast cell cytokine production; positive regulation of mast cell degranulation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of type I hypersensitivity; regulation of immune response; serotonin secretion; signal transduction; type 2 immune response; type I hypersensitivity
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Reference #:
P20489
(UniProtKB)
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Alt. Names/Synonyms: Fc receptor, IgE, high affinity I, alpha polypeptide; Fc-epsilon RI-alpha; FcE; Fce1; Fce1a; fcepsilonri; Fcer1a; FCERA; FcERI; Fcr-; Fcr-5; High affinity immunoglobulin epsilon receptor subunit alpha; IgE Fc receptor subunit alpha
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Gene Symbols: Fcer1a
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Molecular weight:
28,657 Da
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Basal Isoelectric point:
8.99
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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