FABP2 FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum. Note: This description may include information from UniProtKB.
Protein type: Lipid-binding; Transporter
Chromosomal Location of human Ortholog: 4q26
Cellular Component:  apical cortex; cytosol; microvillus; nucleus
Molecular Function:  fatty acid binding; long-chain fatty acid binding; long-chain fatty acid transporter activity; protein binding
Biological Process:  fatty acid metabolic process; fatty acid transport; intestinal lipid absorption; long-chain fatty acid transport
Reference #:  P12104 (UniProtKB)
Alt. Names/Synonyms: FABP2; FABPI; fatty acid binding protein 2; fatty acid binding protein 2, intestinal; Fatty acid-binding protein 2; Fatty acid-binding protein, intestinal; I-FABP; intestinal fatty acid binding protein 2; Intestinal-type fatty acid-binding protein; MGC133132
Gene Symbols: FABP2
Molecular weight: 15,237 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein