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FABP2
FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum. Note: This description may include information from UniProtKB.
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| Protein type: Lipid-binding; Transporter |
| Chromosomal Location of human Ortholog: 4q26 |
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Cellular Component:
apical cortex; cytosol; microvillus; nucleus; plasma membrane
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Molecular Function:
fatty acid binding; long-chain fatty acid binding; long-chain fatty acid transporter activity; protein binding
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Biological Process:
fatty acid metabolic process; fatty acid transport; intestinal lipid absorption; long-chain fatty acid transport
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Reference #:
P12104
(UniProtKB)
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Alt. Names/Synonyms: FABP2; FABPI; fatty acid binding protein 2; fatty acid binding protein 2, intestinal; Fatty acid-binding protein 2; Fatty acid-binding protein, intestinal; I-FABP; intestinal fatty acid binding protein 2; Intestinal-type fatty acid-binding protein; MGC133132
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Gene Symbols: FABP2
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Molecular weight:
15,207 Da
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Basal Isoelectric point:
6.62
Predict pI for various phosphorylation states
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