SRMS Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues. Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues. Phosphorylation of KHDRBS1 is EGF-dependent. Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Highly expressed in most breast cancers (at protein level). Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group
Chromosomal Location of Human Ortholog: -
Cellular Component:  cytoplasm; cytosol
Molecular Function:  ATP binding; protein binding; protein tyrosine kinase activity
Biological Process:  negative regulation of signal transduction; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation
Reference #:  Q9H3Y6 (UniProtKB)
Alt. Names/Synonyms: C20orf148; dJ697K14.1; src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites; SRM; SRMS; Tyrosine-protein kinase Srms
Gene Symbols: SRMS
Molecular weight: 54,507 Da
Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Tyrosine Kinases & Substrates
Select Structure to View Below

SRMS

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene