FRK Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group; Tumor suppressor
Chromosomal Location of Human Ortholog: 20q12
Cellular Component:  cytosol; extrinsic component of cytoplasmic side of plasma membrane; nucleus; plasma membrane
Molecular Function:  ATP binding; non-membrane spanning protein tyrosine kinase activity; protein tyrosine kinase activity; signaling receptor binding
Biological Process:  cell differentiation; negative regulation of transcription by RNA polymerase II; peptidyl-tyrosine autophosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q62662 (UniProtKB)
Alt. Names/Synonyms: Frk; FYN-related kinase; GASK; Gastrointestinal-associated kinase; Gastrointestinal-associated tyrosine kinase; GTK; src related tyrosine kinase; Tyrosine-protein kinase FRK
Gene Symbols: Frk
Molecular weight: 58,166 Da
Basal Isoelectric point: 5.59  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Tyrosine Kinases & Substrates
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FRK

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene