MAFK Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Belongs to the bZIP family. Maf subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 5 G2|5 78.81 cM
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity; protein binding; RING-like zinc finger domain binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription cofactor binding; transcription regulatory region sequence-specific DNA binding
Biological Process:  negative regulation of transcription by RNA polymerase II; nervous system development; regulation of transcription, DNA-templated
Reference #:  Q61827 (UniProtKB)
Alt. Names/Synonyms: AW061068; Erythroid transcription factor NF-E2 p18 subunit; Mafk; NF-E; NF-E2; Nfe2; Nfe2u; nuclear factor, erythroid derived 2, ubiquitous; OTTMUSP00000030611; OTTMUSP00000030612; p18 NF-E2; Transcription factor MafK; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)
Gene Symbols: Mafk
Molecular weight: 17,537 Da
Basal Isoelectric point: 10.1  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene