NACAD May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). Belongs to the NAC-alpha family. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 7p13
Cellular Component:  nascent polypeptide-associated complex; nucleus
Biological Process:  protein transport
Reference #:  O15069 (UniProtKB)
Alt. Names/Synonyms: KIAA0363; NAC alpha domain containing; NAC-alpha domain-containing protein 1; NACAD
Gene Symbols: NACAD
Molecular weight: 161,101 Da
Basal Isoelectric point: 4.12  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB