CRMP-3 Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of mouse Ortholog: 7|7 F4
Cellular Component:  cytoplasm; cytosol
Molecular Function:  filamin binding; hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds; phosphoprotein binding; protein binding
Biological Process:  neuron death; neuron projection guidance
Reference #:  O35098 (UniProtKB)
Alt. Names/Synonyms: AI173505; Collapsin response mediator protein 3; Crm; CRMP; CRMP-3; Crmp3; dihydropyrimidinase-like 4; Dihydropyrimidinase-related protein 4; DPY; DPY4; DPYL4; Dpysl4; Drp; DRP-4; ULIP-4; Ulip4; unc-33-like phosphoprotein 4; UNC33-like phosphoprotein 4
Gene Symbols: Dpysl4
Molecular weight: 61,962 Da
Basal Isoelectric point: 6.51  Predict pI for various phosphorylation states
Select Structure to View Below

CRMP-3

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene