FZD9 Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Belongs to the G-protein coupled receptor Fz/Smo family. Note: This description may include information from UniProtKB.
Protein type: GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component:  cell surface; cytoplasm; endoplasmic reticulum membrane; filopodium membrane; glutamatergic synapse; Golgi apparatus; integral component of membrane; mitochondrial membrane; perinuclear region of cytoplasm; plasma membrane; postsynapse
Molecular Function:  G protein-coupled receptor activity; protein heterodimerization activity; protein homodimerization activity; Wnt-activated receptor activity; Wnt-protein binding
Biological Process:  B cell differentiation; bone regeneration; G protein-coupled receptor signaling pathway; learning or memory; negative regulation of cell cycle arrest; negative regulation of mitochondrial depolarization; negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; negative regulation of necroptotic process; negative regulation of neuron apoptotic process; negative regulation of skeletal muscle acetylcholine-gated channel clustering; nervous system development; neuroblast proliferation; ossification; positive regulation of apoptotic process; positive regulation of bone mineralization; positive regulation of canonical Wnt signaling pathway; positive regulation of neural precursor cell proliferation; postsynapse organization; regulation of cytosolic calcium ion concentration; regulation of postsynaptic cytosolic calcium ion concentration; regulation of skeletal muscle acetylcholine-gated channel clustering; release of cytochrome c from mitochondria
Reference #:  O00144 (UniProtKB)
Alt. Names/Synonyms: CD349; frizzled homolog 9 (Drosophila); Frizzled-9; Fz-9; FZD3; FZD9; FzE6; hFz9
Gene Symbols: FZD9
Molecular weight: 64,466 Da
Basal Isoelectric point: 8.63  Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB