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FRK
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group; Tumor suppressor |
| Chromosomal Location of human Ortholog: 6q22.1 |
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Cellular Component:
azurophil granule lumen; cytosol; extracellular region; nucleus; specific granule lumen
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Molecular Function:
ATP binding; protein binding; protein tyrosine kinase activity
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Biological Process:
negative regulation of cell proliferation; negative regulation of transcription by RNA polymerase II; neutrophil degranulation; protein phosphorylation
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Reference #:
P42685
(UniProtKB)
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Alt. Names/Synonyms: FRK; fyn related Src family tyrosine kinase; FYN-related kinase; GTK; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5; PTK5; PTK5 protein tyrosine kinase 5; RAK; Tyrosine-protein kinase FRK
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Gene Symbols: FRK
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Molecular weight:
58,254 Da
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Basal Isoelectric point:
6.22
Predict pI for various phosphorylation states
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CST Pathways:
GPCR Signaling to MAPKs
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Tyrosine Kinases & Substrates
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