FRK Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group; Tumor suppressor
Chromosomal Location of human Ortholog: 6q22.1
Cellular Component:  azurophil granule lumen; cytosol; extracellular region; nucleus; specific granule lumen
Molecular Function:  ATP binding; protein binding; protein tyrosine kinase activity
Biological Process:  negative regulation of cell proliferation; negative regulation of transcription by RNA polymerase II; neutrophil degranulation; protein phosphorylation
Reference #:  P42685 (UniProtKB)
Alt. Names/Synonyms: FRK; fyn related Src family tyrosine kinase; FYN-related kinase; GTK; Nuclear tyrosine protein kinase RAK; Protein-tyrosine kinase 5; PTK5; PTK5 protein tyrosine kinase 5; RAK; Tyrosine-protein kinase FRK
Gene Symbols: FRK
Molecular weight: 58,254 Da
Basal Isoelectric point: 6.22  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Tyrosine Kinases & Substrates
Select Structure to View Below

FRK

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene