UBE2O
E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins. Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity. Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis. Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location. Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly. Belongs to the ubiquitin-conjugating enzyme family. Predominantly expressed in skeletal muscle and heart. Note: This description may include information from UniProtKB.
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Protein type: EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase |
Chromosomal Location of human Ortholog: 17q25.1 |
Cellular Component:
cytoplasm; cytosol; nuclear body; nucleoplasm; nucleus
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Molecular Function:
ATP binding; protein binding; ubiquitin conjugating enzyme activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
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Biological Process:
positive regulation of BMP signaling pathway; protein K63-linked ubiquitination; protein monoubiquitination; retrograde transport, endosome to Golgi
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Reference #:
Q9C0C9
(UniProtKB)
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Alt. Names/Synonyms: (E3-independent) E2 ubiquitin-conjugating enzyme; E2-230K; E2/E3 hybrid ubiquitin-protein ligase UBE2O; FLJ12878; KIAA1734; UBE2O; Ubiquitin carrier protein O; ubiquitin conjugating enzyme E2 O; ubiquitin conjugating enzyme E2O; Ubiquitin-conjugating enzyme E2 O; Ubiquitin-conjugating enzyme E2 of 230 kDa; Ubiquitin-conjugating enzyme E2-230K; ubiquitin-conjugating enzyme E2O; Ubiquitin-protein ligase O
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Gene Symbols: UBE2O
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Molecular weight:
141,293 Da
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Basal Isoelectric point:
5.01
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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