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ROS
Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Expressed in brain. Expression is increased in primary gliomas. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); Sev family; TK group |
| Chromosomal Location of rat Ortholog: 20q11 |
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Cellular Component:
cell surface; perinuclear region of cytoplasm; plasma membrane; receptor complex
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Molecular Function:
ATP binding; protein phosphatase binding; protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity
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Biological Process:
cell differentiation; columnar/cuboidal epithelial cell development; gene expression; multicellular organism development; negative regulation of gene expression; peptidyl-tyrosine autophosphorylation; positive regulation of kinase activity; protein phosphorylation; regulation of cell growth; regulation of ERK1 and ERK2 cascade; regulation of phosphate transport; regulation of TOR signaling; signal transduction; spermatogenesis; transmembrane receptor protein tyrosine kinase signaling pathway
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Reference #:
Q63132
(UniProtKB)
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Alt. Names/Synonyms: c-ros oncogene 1 , receptor tyrosine kinase; c-ros-1; heart - derived c - ros - 1 proto - oncogene; Proto-oncogene tyrosine-protein kinase ROS; ROS; Ros1; Ros1 proto-oncogene; ROS1C; v-ros UR2 sarcoma virus oncogene homolog 1
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Gene Symbols: Ros1
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Molecular weight:
261,656 Da
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Basal Isoelectric point:
5.79
Predict pI for various phosphorylation states
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CST Pathways:
Tyrosine Kinases & Substrates
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