PDE10A Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. Belongs to the cyclic nucleotide phosphodiesterase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.17; EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase
Chromosomal Location of Human Ortholog: 6q27
Cellular Component:  cytosol; membrane; perikaryon
Molecular Function:  3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cAMP binding; cGMP binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; drug binding; metal ion binding
Biological Process:  cAMP catabolic process; cGMP catabolic process; signal transduction
Reference #:  Q9Y233 (UniProtKB)
Alt. Names/Synonyms: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; dJ416F21.1 (phosphodiesterase 10A); FLJ11894; FLJ25677; HSPDE10A; PDE10; PDE10A; phosphodiesterase 10A; phosphodiesterase 10A1 (PDE10A1)
Gene Symbols: PDE10A
Molecular weight: 88,412 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
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PDE10A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein