ROS Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Expressed in brain. Expression is increased in primary gliomas. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); Sev family; TK group
Chromosomal Location of Human Ortholog: 10 B3|10 26.18 cM
Cellular Component:  cell surface; integral component of membrane; integral component of plasma membrane; membrane; perinuclear region of cytoplasm; plasma membrane; receptor complex
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein phosphatase binding; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process:  cell differentiation; cell proliferation; columnar/cuboidal epithelial cell development; negative regulation of gene expression; peptidyl-tyrosine autophosphorylation; phosphorylation; protein phosphorylation; regulation of cell growth; regulation of ERK1 and ERK2 cascade; regulation of phosphate transport; regulation of TOR signaling; signal transduction by protein phosphorylation; spermatogenesis; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q78DX7 (UniProtKB)
Alt. Names/Synonyms: c-ros; c-Ros receptor tyrosine kinase; c-ros-1; Proto-oncogene c-Ros; Proto-oncogene c-Ros-1; Proto-oncogene tyrosine-protein kinase ROS; Receptor tyrosine kinase c-ros oncogene 1; ROS; Ros-1; Ros1; Ros1 proto-oncogene
Gene Symbols: Ros1
Molecular weight: 261,967 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene