RYK May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. Belongs to the protein kinase superfamily. Tyr protein kinase family. Observed in all the tissues examined. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Ryk family; TK group
Chromosomal Location of Human Ortholog: 9 F1|9 54.72 cM
Cellular Component:  cytoplasm; integral component of membrane; integral component of plasma membrane; membrane; nucleus; plasma membrane; receptor complex
Molecular Function:  ATP binding; frizzled binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; transferase activity; transmembrane signaling receptor activity; Wnt-activated receptor activity; Wnt-protein binding
Biological Process:  axon guidance; axonogenesis; chemorepulsion of axon; chemorepulsion of dopaminergic neuron axon; commissural neuron axon guidance; corpus callosum development; midbrain dopaminergic neuron differentiation; negative chemotaxis; negative regulation of axon extension involved in axon guidance; nervous system development; neuron differentiation; neuron projection development; phosphorylation; planar cell polarity pathway involved in axon guidance; positive regulation of MAPK cascade; protein phosphorylation; skeletal system morphogenesis; transmembrane receptor protein tyrosine kinase signaling pathway; Wnt signaling pathway
Reference #:  Q01887 (UniProtKB)
Alt. Names/Synonyms: AW536699; ERK-; ERK-3; growth factor receptor; Kinase VIK; Met-related kinase; Mrk; NYK-R; receptor-like tyrosine kinase; Ryk; Tyrosine-protein kinase RYK; Vik
Gene Symbols: Ryk
Molecular weight: 66,285 Da
Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene