SLC25A28 Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid cells. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme. Belongs to the mitochondrial carrier (TC 2.A.29) family. Ubiquitous. Expressed in placenta, lung, kidney, pancreas, liver, brain, skeletal muscle and heart. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 10q24.2
Cellular Component:  integral component of membrane; mitochondrial inner membrane
Biological Process:  iron ion homeostasis
Reference #:  Q96A46 (UniProtKB)
Alt. Names/Synonyms: DKFZp547C109; hMRS3/4; MFRN2; Mitochondrial iron transporter 2; mitochondrial RNA splicing protein 3/4; Mitochondrial RNA-splicing protein 3/4 homolog; Mitoferrin-2; MRS3/4; MRS4L; NPD016; putative mitochondrial solute carrier; SLC25A28; Solute carrier family 25 member 28; solute carrier family 25, member 28
Gene Symbols: SLC25A28
Molecular weight: 39,272 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
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SLC25A28

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene