RYK May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. Belongs to the protein kinase superfamily. Tyr protein kinase family. Observed in all the tissues examined. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Ryk family; TK group
Chromosomal Location of human Ortholog: 3q22.2
Cellular Component:  cytoplasm; integral component of membrane; membrane; nucleus; plasma membrane
Molecular Function:  ATP binding; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway; frizzled binding; protein binding; transmembrane signaling receptor activity; Wnt-activated receptor activity; Wnt-protein binding
Biological Process:  axon guidance; axonogenesis; canonical Wnt signaling pathway; cell proliferation in midbrain; chemorepulsion of dopaminergic neuron axon; commissural neuron axon guidance; corpus callosum development; midbrain dopaminergic neuron differentiation; negative regulation of axon extension involved in axon guidance; neurogenesis; neuron differentiation; neuron projection development; non-canonical Wnt signaling pathway; peptidyl-tyrosine phosphorylation; planar cell polarity pathway involved in axon guidance; positive regulation of MAPK cascade; signal transduction; skeletal system morphogenesis; synapse assembly; Wnt signaling pathway; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
Reference #:  P34925 (UniProtKB)
Alt. Names/Synonyms: D3S3195; hydroxyaryl-protein kinase; JTK5; JTK5A; JTK5A protein tyrosine kinase; receptor like tyrosine kinase; RYK; RYK receptor-like tyrosine kinase; RYK1; Tyrosine-protein kinase RYK
Gene Symbols: RYK
Molecular weight: 67,507 Da
Basal Isoelectric point: 7.52  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene