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ROR1
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Ror family; TK group |
| Chromosomal Location of mouse Ortholog: 4 C6|4 45.71 cM |
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Cellular Component:
axon terminus; cell projection; cell surface; membrane; plasma membrane; receptor complex; stress fiber
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Molecular Function:
ATP binding; nucleotide binding; protein kinase activity; transmembrane receptor protein tyrosine kinase activity; Wnt receptor activity; Wnt-protein binding
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Biological Process:
astrocyte development; inner ear development; multicellular organism development; positive regulation of ERK1 and ERK2 cascade; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of kinase activity; positive regulation of neuron projection development; positive regulation of NF-kappaB transcription factor activity; positive regulation of phosphatidylinositol 3-kinase signaling; protein phosphorylation; sensory perception of sound; transmembrane receptor protein tyrosine kinase signaling pathway; Wnt signaling pathway
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Reference #:
Q9Z139
(UniProtKB)
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Alt. Names/Synonyms: 2810404D04Rik; Inactive tyrosine-protein kinase transmembrane receptor ROR1; mROR1; neurotrophic tyrosine kinase, receptor related 1; Neurotrophic tyrosine kinase, receptor-related 1; Ntr; Ntrkr1; OTTMUSP00000008344; receptor tyrosine kinase-like orphan receptor 1; Ror1; RP23-408D7.2; Tyrosine-protein kinase transmembrane receptor ROR1
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Gene Symbols: Ror1
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Molecular weight:
104,088 Da
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Basal Isoelectric point:
6.87
Predict pI for various phosphorylation states
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CST Pathways:
Tyrosine Kinases & Substrates
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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