TAF1A Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 1|1 H5
Cellular Component:  microtubule cytoskeleton; nucleoplasm; nucleus; RNA polymerase I transcription factor complex
Molecular Function:  DNA binding; protein binding
Biological Process:  transcription by RNA polymerase I
Reference #:  P97357 (UniProtKB)
Alt. Names/Synonyms: mTAFI48; RNA polymerase I-specific TBP-associated factor 48 kDa; Taf1a; TAFI48; TATA box binding protein (Tbp)-associated factor, RNA polymerase I, A; TATA box-binding protein-associated factor 1A; TATA box-binding protein-associated factor RNA polymerase I subunit A; TBP-associated factor 1A; Transcription initiation factor SL1/TIF-IB subunit A
Gene Symbols: Taf1a
Molecular weight: 52,718 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene