ROR1 Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Ror family; TK group
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component:  axon terminus; cell surface; cytoplasm; plasma membrane; receptor complex; stress fiber
Molecular Function:  ATP binding; coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway; protein binding; Wnt-activated receptor activity; Wnt-protein binding
Biological Process:  astrocyte development; inner ear development; peptidyl-tyrosine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; sensory perception of sound; Wnt signaling pathway, planar cell polarity pathway
Disease: Deafness, Autosomal Recessive 108
Reference #:  Q01973 (UniProtKB)
Alt. Names/Synonyms: dJ537F10.1; Inactive tyrosine-protein kinase transmembrane receptor ROR1; MGC99659; neurotrophic tyrosine kinase receptor-related 1; Neurotrophic tyrosine kinase, receptor-related 1; NTRKR1; receptor tyrosine kinase like orphan receptor 1; receptor tyrosine kinase-like orphan receptor 1; ROR1; Tyrosine-protein kinase transmembrane receptor ROR1
Gene Symbols: ROR1
Molecular weight: 104,283 Da
Basal Isoelectric point: 6.76  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ROR1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene