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Ron
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand. Belongs to the protein kinase superfamily. Tyr protein kinase family. Expressed in colon, skin, lung and bone marrow. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Met family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group |
| Chromosomal Location of mouse Ortholog: 9 59.07 cM|9 F1 |
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Cellular Component:
membrane; plasma membrane; receptor complex; stress fiber; vacuole
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Molecular Function:
ATP binding; enzyme binding; kinase activity; nucleotide binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity
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Biological Process:
cell migration; immune system process; innate immune response; multicellular organism development; nervous system development; phagocytosis; phosphorylation; positive regulation of kinase activity; positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling; protein phosphorylation; response to virus; transmembrane receptor protein tyrosine kinase signaling pathway
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Reference #:
Q62190
(UniProtKB)
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Alt. Names/Synonyms: c-met-related tyrosine kinase; CD136; CDw136; friend virus susceptibility 2; Fv-; Fv-2; Fv2; macrophage stimulating 1 receptor (c-met-related tyrosine kinase); Macrophage-stimulating protein receptor; Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain; macrophage-stimulating protein receptor precursor (MSP receptor) (p185-Ron) (Stem cell-derived tyrosine kinase); MSP receptor; Mst1r; p185-Ron; PTK; PTK8; receptor protein tyrosine kinase, c-met-related; Ron; Stem cell-derived tyrosine kinase; Stk
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Gene Symbols: Mst1r
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Molecular weight:
150,519 Da
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Basal Isoelectric point:
6.71
Predict pI for various phosphorylation states
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CST Pathways:
Tyrosine Kinases & Substrates
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