TPCN2 Nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane. May be involved in smooth muscle contraction. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. Two pore calcium channel subfamily. Widely expressed. Expressed at high level in liver and kidney. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of human Ortholog: 11q13.3
Cellular Component:  endosome membrane; integral component of membrane; lysosomal membrane; lysosome
Molecular Function:  identical protein binding; NAADP-sensitive calcium-release channel activity; protein binding; protein kinase binding; voltage-gated calcium channel activity
Biological Process:  calcium-mediated signaling; cellular calcium ion homeostasis; ion transmembrane transport; lysosome organization; regulation of autophagy; regulation of ion transmembrane transport; release of sequestered calcium ion into cytosol; response to vitamin D; smooth muscle contraction
Disease: Skin/hair/eye Pigmentation, Variation In, 10
Reference #:  Q8NHX9 (UniProtKB)
Alt. Names/Synonyms: FLJ41094; SHEP10; TPC2; TPCN2; Two pore calcium channel protein 2; two pore segment channel 2; two-pore calcium channel protein 2; Voltage-dependent calcium channel protein TPC2
Gene Symbols: TPCN2
Molecular weight: 85,243 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene