|
MAN1C1
Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc. Belongs to the glycosyl hydrolase 47 family. Expressed in most tissues with the exception of lung, muscle and pancreas. Highly expressed in placenta. Note: This description may include information from UniProtKB.
|
| Protein type: Calcium-binding; EC 3.2.1.113; Glycan Metabolism - N-glycan biosynthesis; Hydrolase; Membrane protein, integral |
| Chromosomal Location of human Ortholog: 1p36.11 |
|
Cellular Component:
endoplasmic reticulum; Golgi membrane
|
|
Molecular Function:
calcium ion binding; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; protein binding
|
|
Biological Process:
carbohydrate metabolic process; Golgi apparatus mannose trimming; mannose trimming involved in glycoprotein ERAD pathway; protein N-linked glycosylation
|
|
Reference #:
Q9NR34
(UniProtKB)
|
|
Alt. Names/Synonyms: 1,2-alpha-mannosidase IC; Alpha-1,2-mannosidase IC; HMIC; MA1C1; MAN1A3; MAN1C; MAN1C1; Mannosidase alpha class 1C member 1; mannosidase, alpha, class 1C, member 1; Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC; pp6318; Processing alpha-1,2-mannosidase IC
|
|
Gene Symbols: MAN1C1
|
|
Molecular weight:
70,911 Da
|
|
Basal Isoelectric point:
7.01
Predict pI for various phosphorylation states
|
