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NDUFS2
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I 49 kDa subunit family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase |
| Chromosomal Location of human Ortholog: 1q23.3 |
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Cellular Component:
mitochondrial matrix; mitochondrial respiratory chain complex I; mitochondrion; nucleoplasm
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Molecular Function:
4 iron, 4 sulfur cluster binding; electron transfer activity; metal ion binding; NAD binding; NADH dehydrogenase (ubiquinone) activity; NADH dehydrogenase activity; oxygen sensor activity; protein binding; quinone binding; ubiquitin protein ligase binding
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Biological Process:
aerobic respiration; cellular response to oxygen levels; gliogenesis; mitochondrial ATP synthesis coupled electron transport; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; neural precursor cell proliferation; neurogenesis; proton motive force-driven mitochondrial ATP synthesis; response to oxidative stress
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Disease: Mitochondrial Complex I Deficiency, Nuclear Type 6
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Reference #:
O75306
(UniProtKB)
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Alt. Names/Synonyms: CI-49; CI-49kD; complex 1, mitochondrial respiratory chain, 49-KD subunit; complex I 49kDa subunit; Complex I-49kD; MC1DN6; NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; NADH-ubiquinone oxidoreductase 49 kDa subunit; NADH-ubiquinone oxidoreductase NDUFS2 subunit; NADH:ubiquinone oxidoreductase core subunit S2; NDUFS2; NDUS2
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Gene Symbols: NDUFS2
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Molecular weight:
52,546 Da
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Basal Isoelectric point:
7.21
Predict pI for various phosphorylation states
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