NDUFS2 Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Belongs to the complex I 49 kDa subunit family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase
Chromosomal Location of human Ortholog: 1q23.3
Cellular Component:  mitochondrial matrix; mitochondrial respiratory chain complex I; mitochondrion; nucleoplasm
Molecular Function:  4 iron, 4 sulfur cluster binding; electron transfer activity; metal ion binding; NAD binding; NADH dehydrogenase (ubiquinone) activity; NADH dehydrogenase activity; oxygen sensor activity; protein binding; quinone binding; ubiquitin protein ligase binding
Biological Process:  aerobic respiration; cellular response to oxygen levels; gliogenesis; mitochondrial ATP synthesis coupled electron transport; mitochondrial electron transport, NADH to ubiquinone; mitochondrial respiratory chain complex I assembly; neural precursor cell proliferation; neurogenesis; proton motive force-driven mitochondrial ATP synthesis; response to oxidative stress
Disease: Mitochondrial Complex I Deficiency, Nuclear Type 6
Reference #:  O75306 (UniProtKB)
Alt. Names/Synonyms: CI-49; CI-49kD; complex 1, mitochondrial respiratory chain, 49-KD subunit; complex I 49kDa subunit; Complex I-49kD; MC1DN6; NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial; NADH-ubiquinone oxidoreductase 49 kDa subunit; NADH-ubiquinone oxidoreductase NDUFS2 subunit; NADH:ubiquinone oxidoreductase core subunit S2; NDUFS2; NDUS2
Gene Symbols: NDUFS2
Molecular weight: 52,546 Da
Basal Isoelectric point: 7.21  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein