ATF6A Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. Belongs to the bZIP family. ATF subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Transcription factor
Chromosomal Location of Human Ortholog: 1q23.3
Cellular Component:  cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; integral component of endoplasmic reticulum membrane; membrane; nuclear envelope; nucleoplasm; nucleus
Molecular Function:  cAMP response element binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding; protein binding; protein heterodimerization activity; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transcription coactivator activity; transcription regulatory region sequence-specific DNA binding; ubiquitin protein ligase binding
Biological Process:  ATF6-mediated unfolded protein response; endoplasmic reticulum unfolded protein response; eye development; positive regulation of apoptotic process; positive regulation of ATF6-mediated unfolded protein response; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; protein folding; regulation of transcription by RNA polymerase II; signal transduction; visual perception
Disease: Achromatopsia 7
Reference #:  P18850 (UniProtKB)
Alt. Names/Synonyms: activating transcription factor 6; Activating transcription factor 6 alpha; ATF6; ATF6-alpha; ATF6A; cAMP-dependent transcription factor ATF-6 alpha; Cyclic AMP-dependent transcription factor ATF-6 alpha; Processed cyclic AMP-dependent transcription factor ATF-6 alpha
Gene Symbols: ATF6
Molecular weight: 74,585 Da
Basal Isoelectric point: 8.36  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene