|
UNC45B
Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. Is necessary for normal early lens development. Expressed in eye lens tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Chromosomal Location of mouse Ortholog: 11|11 C |
|
Cellular Component:
cytoplasm; cytosol
|
|
Molecular Function:
Hsp90 protein binding
|
|
Biological Process:
cell differentiation; chaperone-mediated protein folding; multicellular organism development; muscle organ development
|
|
Reference #:
Q8CGY6
(UniProtKB)
|
|
Alt. Names/Synonyms: AA445617; cardiomyopathy associated 4; Cmya; Cmya4; D230041A13Rik; MGC91090; Protein unc-45 homolog B; striated muscle UNC45; UN45B; unc-45 homolog B; unc-45 homolog B (C. elegans); unc-45 myosin chaperone B; Unc-45B; UNC4; Unc45; Unc45b
|
|
Gene Symbols: Unc45b
|
|
Molecular weight:
103,638 Da
|
|
Basal Isoelectric point:
8.26
Predict pI for various phosphorylation states
|
