Lmr3 Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons. Belongs to the protein kinase superfamily. Tyr protein kinase family. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Lmr family; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of human Ortholog: 19q13.33
Cellular Component:  axon; dendrite; Golgi membrane; integral component of membrane
Molecular Function:  ATP binding; metal ion binding; protein binding; protein serine/threonine kinase activity
Biological Process:  negative regulation of phosphatase activity; protein phosphorylation
Reference #:  Q96Q04 (UniProtKB)
Alt. Names/Synonyms: KIAA1883; Lemur tyrosine kinase 3; LMR3; LMTK3; PPP1R101; protein phosphatase 1, regulatory subunit 101; Serine/threonine-protein kinase LMTK3; TYKLM3
Gene Symbols: LMTK3
Molecular weight: 153,661 Da
Basal Isoelectric point: 4.77  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein