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Lmr3
Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription. Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons. Belongs to the protein kinase superfamily. Tyr protein kinase family. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; Lmr family; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group |
| Chromosomal Location of human Ortholog: 19q13.33 |
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Cellular Component:
axon; dendrite; Golgi membrane
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Molecular Function:
ATP binding; metal ion binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
protein phosphorylation
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Reference #:
Q96Q04
(UniProtKB)
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Alt. Names/Synonyms: KIAA1883; Lemur tyrosine kinase 3; LMR3; LMTK3; PPP1R101; protein phosphatase 1, regulatory subunit 101; Serine/threonine-protein kinase LMTK3; TYKLM3
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Gene Symbols: LMTK3
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Molecular weight:
153,661 Da
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Basal Isoelectric point:
4.77
Predict pI for various phosphorylation states
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CST Pathways:
Tyrosine Kinases & Substrates
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