Lmr1 a protein kinase kinase of the Lmr family. Predominantly expressed in the nervous system and is involved in neurite extension and apoptosis of cerebellar granule cells. Contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. May be necessary for the induction of growth arrest and/or apoptosis of myeloid cells induced by cytokine withdrawal, such as IL3, and during G-CSF-induced terminal differentiation of myeloblasts to granulocytes. Four alternatively spliced isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Lmr family; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component:  integral component of membrane; perinuclear region of cytoplasm
Molecular Function:  ATP binding; protein serine/threonine kinase activity
Biological Process:  protein phosphorylation
Reference #:  Q6ZMQ8 (UniProtKB)
Alt. Names/Synonyms: AATK; AATYK; AATYK1; Apoptosis-associated tyrosine kinase; Brain apoptosis-associated tyrosine kinase; CDK5-binding protein; KIAA0641; Lemur tyrosine kinase 1; LMR1; LMTK1; p35-binding protein; p35BP; Serine/threonine-protein kinase LMTK1
Gene Symbols: AATK
Molecular weight: 144,569 Da
Basal Isoelectric point: 4.48  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein