PLXNB2 Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42. Down-regulates macrophage migration in wound- healing assays (in vitro). Belongs to the plexin family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 15 E3|15 44.68 cM
Cellular Component:  integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; semaphorin receptor complex
Molecular Function:  protein binding; semaphorin receptor activity
Biological Process:  brain development; excitatory synapse assembly; homophilic cell adhesion via plasma membrane adhesion molecules; multicellular organism development; negative regulation of cell adhesion; neural tube closure; neuroblast proliferation; positive regulation of axonogenesis; positive regulation of neuron projection development; regulation of cell migration; regulation of cell shape; regulation of GTPase activity; regulation of neuron migration; regulation of protein phosphorylation; semaphorin-plexin signaling pathway; semaphorin-plexin signaling pathway involved in axon guidance; signal transduction
Reference #:  B2RXS4 (UniProtKB)
Alt. Names/Synonyms: 1110007H23Rik; Debt; differentially expressed in brain tumors; mKIAA0315; OTTMUSP00000023076; plexin B2; Plexin-B2; Plxnb2
Gene Symbols: Plxnb2
Molecular weight: 206,230 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
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PLXNB2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene