IRR Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; InsR family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of human Ortholog: 1q23.1
Cellular Component:  axon; insulin receptor complex; plasma membrane; receptor complex
Molecular Function:  ATP binding; insulin receptor activity; insulin receptor substrate binding; phosphatidylinositol 3-kinase binding; protein binding; transmembrane receptor protein tyrosine kinase activity
Biological Process:  actin cytoskeleton organization; cellular response to alkaline pH; insulin receptor signaling pathway; male sex determination; multicellular organism development; positive regulation of kinase activity; protein autophosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P14616 (UniProtKB)
Alt. Names/Synonyms: INSRR; insulin receptor related receptor; Insulin receptor-related protein; Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain; insulin receptor-related receptor; IR-related receptor; IRR
Gene Symbols: INSRR
Molecular weight: 143,720 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below

IRR

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein