IRR Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; InsR family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 1q23.1
Cellular Component:  axon; cytoplasm; insulin receptor complex; integral component of plasma membrane; receptor complex
Molecular Function:  ATP binding; insulin receptor substrate binding; insulin-activated receptor activity; MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding; phosphoinositide 3-kinase binding; protein tyrosine kinase activity; transmembrane receptor activity; transmembrane receptor protein tyrosine kinase activity
Biological Process:  actin cytoskeleton reorganization; cell differentiation; cellular response to alkaline pH; glucose homeostasis; male sex determination; multicellular organism development; negative regulation of apoptosis; negative regulation of signal transduction; peptidyl-tyrosine phosphorylation; positive regulation of ERK1 and ERK2 cascade; positive regulation of kinase activity; positive regulation of protein phosphorylation; protein autophosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P14616 (UniProtKB)
Alt. Names/Synonyms: INSRR; Insulin receptor-related protein; Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain; insulin receptor-related receptor; IR-related receptor; IRR
Gene Symbols: INSRR
Molecular weight: 143,720 Da
Basal Isoelectric point: 6.03  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below

IRR

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene