IRR
Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. Note: This description may include information from UniProtKB.
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Protein type: EC 2.7.10.1; InsR family; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group |
Chromosomal Location of human Ortholog: 1q23.1 |
Cellular Component:
axon; insulin receptor complex; plasma membrane; receptor complex
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Molecular Function:
ATP binding; insulin receptor activity; insulin receptor substrate binding; phosphatidylinositol 3-kinase binding; protein binding; transmembrane receptor protein tyrosine kinase activity
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Biological Process:
actin cytoskeleton organization; cellular response to alkaline pH; insulin receptor signaling pathway; male sex determination; multicellular organism development; positive regulation of kinase activity; protein autophosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
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Reference #:
P14616
(UniProtKB)
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Alt. Names/Synonyms: INSRR; insulin receptor related receptor; Insulin receptor-related protein; Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain; insulin receptor-related receptor; IR-related receptor; IRR
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Gene Symbols: INSRR
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Molecular weight:
143,720 Da
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Basal Isoelectric point:
6.03
Predict pI for various phosphorylation states
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CST Pathways:
Tyrosine Kinases & Substrates
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