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BLMH
The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. Belongs to the peptidase C1 family. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.22.40; Protease |
| Chromosomal Location of human Ortholog: 17q11.2 |
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Cellular Component:
cytoplasm; cytosol
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Molecular Function:
aminopeptidase activity; carboxypeptidase activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; identical protein binding; protein binding
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Biological Process:
homocysteine catabolic process; protein polyubiquitination; proteolysis; response to toxic substance; response to xenobiotic stimulus
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Disease: Alzheimer Disease
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Reference #:
Q13867
(UniProtKB)
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Alt. Names/Synonyms: BH; Bleomycin hydrolase; BLM hydrolase; BLMH; BMH
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Gene Symbols: BLMH
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Molecular weight:
52,562 Da
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Basal Isoelectric point:
5.87
Predict pI for various phosphorylation states
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