BLMH The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity. Belongs to the peptidase C1 family. Note: This description may include information from UniProtKB.
Protein type: EC; Protease
Chromosomal Location of human Ortholog: 17q11.2
Cellular Component:  cytoplasm; cytosol
Molecular Function:  aminopeptidase activity; carboxypeptidase activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; identical protein binding; protein binding
Biological Process:  homocysteine catabolic process; protein polyubiquitination; proteolysis; response to toxic substance; response to xenobiotic stimulus
Disease: Alzheimer Disease
Reference #:  Q13867 (UniProtKB)
Alt. Names/Synonyms: BH; Bleomycin hydrolase; BLM hydrolase; BLMH; BMH
Gene Symbols: BLMH
Molecular weight: 52,562 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene