SMPDL3B Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling. Has in vitro phosphodiesterase activity, but the physiological substrate is unknown. Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro). Belongs to the acid sphingomyelinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.-; Phosphodiesterase; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 1p35.3
Cellular Component:  extracellular space; plasma membrane
Molecular Function:  hydrolase activity, acting on glycosyl bonds; phosphoric diester hydrolase activity; sphingomyelin phosphodiesterase activity; zinc ion binding
Biological Process:  inflammatory response; innate immune response; membrane lipid catabolic process; negative regulation of inflammatory response; negative regulation of toll-like receptor signaling pathway; sphingomyelin catabolic process
Reference #:  Q92485 (UniProtKB)
Alt. Names/Synonyms: Acid sphingomyelinase-like phosphodiesterase 3b; ASM-like phosphodiesterase 3b; ASM3B; ASML3B; ASMLPD; SMPDL3B; sphingomyelin phosphodiesterase acid like 3B; sphingomyelin phosphodiesterase, acid-like 3B
Gene Symbols: SMPDL3B
Molecular weight: 50,814 Da
Basal Isoelectric point: 5.36  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein