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SMPDL3B
Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling. Has in vitro phosphodiesterase activity, but the physiological substrate is unknown. Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro). Belongs to the acid sphingomyelinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.4.-; Phosphodiesterase; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 1p35.3 |
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Cellular Component:
extracellular space; plasma membrane
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Molecular Function:
hydrolase activity, acting on glycosyl bonds; phosphoric diester hydrolase activity; sphingomyelin phosphodiesterase activity; zinc ion binding
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Biological Process:
inflammatory response; innate immune response; membrane lipid catabolic process; negative regulation of inflammatory response; negative regulation of toll-like receptor signaling pathway; sphingomyelin catabolic process
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Reference #:
Q92485
(UniProtKB)
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Alt. Names/Synonyms: Acid sphingomyelinase-like phosphodiesterase 3b; ASM-like phosphodiesterase 3b; ASM3B; ASML3B; ASMLPD; SMPDL3B; sphingomyelin phosphodiesterase acid like 3B; sphingomyelin phosphodiesterase, acid-like 3B
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Gene Symbols: SMPDL3B
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Molecular weight:
50,814 Da
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Basal Isoelectric point:
5.36
Predict pI for various phosphorylation states
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