FGG Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. Detected in blood plasma (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3 E3|3 36.94 cM
Cellular Component:  blood microparticle; cell cortex; cell surface; cytoplasm; external side of plasma membrane; extracellular region; extracellular space; fibrinogen complex; platelet alpha granule; synapse
Molecular Function:  cell adhesion molecule binding; extracellular matrix structural constituent; metal ion binding; protein homodimerization activity; signaling receptor binding; structural molecule activity
Biological Process:  adaptive immune response; blood coagulation; blood coagulation, fibrin clot formation; cell-matrix adhesion; cellular protein-containing complex assembly; fibrinolysis; hemostasis; immune system process; innate immune response; negative regulation of endothelial cell apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of platelet aggregation; plasminogen activation; platelet activation; platelet aggregation; positive regulation of ERK1 and ERK2 cascade; positive regulation of exocytosis; positive regulation of heterotypic cell-cell adhesion; positive regulation of peptide hormone secretion; positive regulation of protein secretion; positive regulation of vasoconstriction; protein polymerization; protein secretion; response to calcium ion
Reference #:  Q8VCM7 (UniProtKB)
Alt. Names/Synonyms: 3010002H13Rik; AI256424; Fgg; FIBG; Fibrinogen gamma chain; fibrinogen gamma-chain; fibrinogen, gamma polypeptide; gamma-fibrinogen
Gene Symbols: Fgg
Molecular weight: 49,391 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene