FGG Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Defects in FGG are a cause of congenital afibrinogenemia (CAFBN). This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 3 E3|3 36.94 cM
Cellular Component:  blood microparticle; cell cortex; cell surface; cytoplasm; external side of plasma membrane; extracellular region; extracellular space; fibrinogen complex; platelet alpha granule; synapse
Molecular Function:  cell adhesion molecule binding; extracellular matrix structural constituent; metal ion binding; protein homodimerization activity; signaling receptor binding; structural molecule activity
Biological Process:  adaptive immune response; blood coagulation; blood coagulation, fibrin clot formation; cell-matrix adhesion; cellular protein-containing complex assembly; fibrinolysis; hemostasis; immune system process; innate immune response; negative regulation of endothelial cell apoptotic process; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of platelet aggregation; plasminogen activation; platelet activation; platelet aggregation; positive regulation of ERK1 and ERK2 cascade; positive regulation of exocytosis; positive regulation of heterotypic cell-cell adhesion; positive regulation of peptide hormone secretion; positive regulation of protein secretion; positive regulation of vasoconstriction; protein polymerization; protein secretion; response to calcium ion
Reference #:  Q8VCM7 (UniProtKB)
Alt. Names/Synonyms: 3010002H13Rik; AI256424; Fgg; FIBG; Fibrinogen gamma chain; fibrinogen gamma-chain; fibrinogen, gamma polypeptide; gamma-fibrinogen
Gene Symbols: Fgg
Molecular weight: 49,391 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene