KMO Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. Belongs to the aromatic-ring hydroxylase family. KMO subfamily. Highest levels in placenta and liver. Detectable in kidney. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; EC 1.14.13.9; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase
Chromosomal Location of human Ortholog: 1q43
Cellular Component:  cytosol; extracellular space; mitochondrial outer membrane
Molecular Function:  FAD binding; flavin adenine dinucleotide binding; kynurenine 3-monooxygenase activity; NAD(P)H oxidase H2O2-forming activity
Biological Process:  'de novo' NAD biosynthetic process from tryptophan; aging; anthranilate metabolic process; cellular response to interleukin-1; cellular response to lipopolysaccharide; kynurenic acid biosynthetic process; kynurenine metabolic process; L-kynurenine metabolic process; NAD metabolic process; positive regulation of glutamate secretion, neurotransmission; positive regulation of neuron death; quinolinate biosynthetic process; response to salt stress; tryptophan catabolic process
Reference #:  O15229 (UniProtKB)
Alt. Names/Synonyms: dJ317G22.1; KMO; Kynurenine 3-hydroxylase; Kynurenine 3-monooxygenase; kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
Gene Symbols: KMO
Molecular weight: 55,810 Da
Basal Isoelectric point: 9.18  Predict pI for various phosphorylation states
Select Structure to View Below

KMO

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene